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PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues

In their active hypophosphorylated state, members of the retinoblastoma family of pocket proteins negatively regulate cell cycle progression at least in part by repressing expression of E2F-dependent genes. Mitogen-dependent activation of G1 and G1/S Cyclin Dependent Kinases (CDKs) results in coordi...

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Detalles Bibliográficos
Autores principales: Kurimchak, Alison, Graña, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612414/
https://www.ncbi.nlm.nih.gov/pubmed/25483052
http://dx.doi.org/10.4161/15384101.2014.985069