Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate

PURPOSE: To estimate the rate constant for pyruvate to lactate conversion in tumours in response to a hypoxic challenge, using hyperpolarised (13)C(1)-pyruvate and magnetic resonance spectroscopy. METHODS AND MATERIALS: Hypoxic inspired gas was used to manipulate rat P22 fibrosarcoma oxygen tension...

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Detalles Bibliográficos
Autores principales: Bluff, Joanne E., Reynolds, Steven, Metcalf, Stephen, Alizadeh, Tooba, Kazan, Samira M., Bucur, Adriana, Wholey, Emily G., Bibby, Becky A.S., Williams, Leigh, Paley, Martyn N., Tozer, Gillian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Scientific Publishers 2015
Materias:
Hypoxia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612449/
https://www.ncbi.nlm.nih.gov/pubmed/25824978
http://dx.doi.org/10.1016/j.radonc.2015.03.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612449/
https://www.ncbi.nlm.nih.gov/pubmed/25824978
http://dx.doi.org/10.1016/j.radonc.2015.03.011

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