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Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate

PURPOSE: To estimate the rate constant for pyruvate to lactate conversion in tumours in response to a hypoxic challenge, using hyperpolarised (13)C(1)-pyruvate and magnetic resonance spectroscopy. METHODS AND MATERIALS: Hypoxic inspired gas was used to manipulate rat P22 fibrosarcoma oxygen tension...

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Detalles Bibliográficos
Autores principales:	Bluff, Joanne E., Reynolds, Steven, Metcalf, Stephen, Alizadeh, Tooba, Kazan, Samira M., Bucur, Adriana, Wholey, Emily G., Bibby, Becky A.S., Williams, Leigh, Paley, Martyn N., Tozer, Gillian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Scientific Publishers 2015
Materias:	Hypoxia
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612449/ https://www.ncbi.nlm.nih.gov/pubmed/25824978 http://dx.doi.org/10.1016/j.radonc.2015.03.011

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