A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors. We discover a macromolecular complex between the scaffolding protein Gravin/AKAP12 and the mitotic kinases, Aurora A and Plk1, that i...

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Detalles Bibliográficos
Autores principales: Hehnly, Heidi, Canton, David, Bucko, Paula, Langeberg, Lorene K, Ogier, Leah, Gelman, Irwin, Santana, L Fernando, Wordeman, Linda, Scott, John D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612572/
https://www.ncbi.nlm.nih.gov/pubmed/26406118
http://dx.doi.org/10.7554/eLife.09384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612572/
https://www.ncbi.nlm.nih.gov/pubmed/26406118
http://dx.doi.org/10.7554/eLife.09384

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