Insight into the Structural Determinants of Imidazole Scaffold-Based Derivatives as TNF-α Release Inhibitors by in Silico Explorations

Presently, 151 widely-diverse pyridinylimidazole-based compounds that show inhibitory activities at the TNF-α release were investigated. By using the distance comparison technique (DISCOtech), comparative molecular field analysis (CoMFA), and comparative molecular similarity index analysis (CoMSIA)...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yuan, Wu, Mingwei, Ai, Chunzhi, Wang, Yonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613192/
https://www.ncbi.nlm.nih.gov/pubmed/26307982
http://dx.doi.org/10.3390/ijms160920118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613192/
https://www.ncbi.nlm.nih.gov/pubmed/26307982
http://dx.doi.org/10.3390/ijms160920118

Ejemplares similares