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Insight into the Structural Determinants of Imidazole Scaffold-Based Derivatives as TNF-α Release Inhibitors by in Silico Explorations

Presently, 151 widely-diverse pyridinylimidazole-based compounds that show inhibitory activities at the TNF-α release were investigated. By using the distance comparison technique (DISCOtech), comparative molecular field analysis (CoMFA), and comparative molecular similarity index analysis (CoMSIA)...

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Detalles Bibliográficos
Autores principales:	Wang, Yuan, Wu, Mingwei, Ai, Chunzhi, Wang, Yonghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613192/ https://www.ncbi.nlm.nih.gov/pubmed/26307982 http://dx.doi.org/10.3390/ijms160920118

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