Mitochondrial Malfunctioning, Proteasome Arrest and Apoptosis in Cancer Cells by Focused Intracellular Generation of Oxygen Radicals

Photofrin/photodynamic therapy (PDT) at sub-lethal doses induced a transient stall in proteasome activity in surviving A549 (p53(+/+)) and H1299 (p53(−/−)) cells as indicated by the time-dependent decline/recovery of chymotrypsin-like activity. Indeed, within 3 h of incubation, Photofrin invaded the...

Descripción completa

Detalles Bibliográficos
Autores principales: Postiglione, Ilaria, Chiaviello, Angela, Barra, Federica, Roscetto, Emanuela, Soriano, Amata A., Catania, Maria Rosaria, Palumbo, Giuseppe, Pierantoni, Giovanna Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613209/
https://www.ncbi.nlm.nih.gov/pubmed/26343643
http://dx.doi.org/10.3390/ijms160920375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613209/
https://www.ncbi.nlm.nih.gov/pubmed/26343643
http://dx.doi.org/10.3390/ijms160920375

Ejemplares similares