Chemically Bonding of Amantadine with Gardenamide A Enhances the Neuroprotective Effects against Corticosterone-Induced Insults in PC12 Cells

Two amantadine (ATD)-gardenamide A (GA) ligands have been designed and synthesized. The bonding of ATD with GA through a methylene carbonyl brigde (L1) enhances the neuroprotective effect against corticosterone (CORT)-induced impairments in PC12 cells; while the bonding through a succinyl brigde (L2...

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Detalles Bibliográficos
Autores principales: Zhao, Jiaqiang, Peng, Lizhi, Zheng, Wenhua, Wang, Rikang, Zhang, Lei, Yang, Jian, Chen, Heru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613336/
https://www.ncbi.nlm.nih.gov/pubmed/26402670
http://dx.doi.org/10.3390/ijms160922795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613336/
https://www.ncbi.nlm.nih.gov/pubmed/26402670
http://dx.doi.org/10.3390/ijms160922795

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