Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers

Colorectal cancer (CRC) is a heterogeneous disease with multiple underlying causative genetic mutations. Genetic mutations in the phosphatidylinositol-3 kinase (PI3K) and the mitogen activated protein kinase (MAPK) pathways are frequently implicated in CRC. Targeting the downstream substrate MEK in...

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Detalles Bibliográficos
Autores principales: Temraz, Sally, Mukherji, Deborah, Shamseddine, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613347/
https://www.ncbi.nlm.nih.gov/pubmed/26404261
http://dx.doi.org/10.3390/ijms160922976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613347/
https://www.ncbi.nlm.nih.gov/pubmed/26404261
http://dx.doi.org/10.3390/ijms160922976

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