LRRK2 dephosphorylation increases its ubiquitination

Activating mutations in the leucine rich repeat protein kinase 2 (LRRK2) gene are the most common cause of inherited Parkinson's disease (PD). LRRK2 is phosphorylated on a cluster of phosphosites including Ser(910), Ser(935), Ser(955) and Ser(973), which are dephosphorylated in several PD-relat...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Jing, Molitor, Tyler P., Langston, J. William, Nichols, R. Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613513/
https://www.ncbi.nlm.nih.gov/pubmed/25939886
http://dx.doi.org/10.1042/BJ20141305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613513/
https://www.ncbi.nlm.nih.gov/pubmed/25939886
http://dx.doi.org/10.1042/BJ20141305

Ejemplares similares