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LRRK2 dephosphorylation increases its ubiquitination

Activating mutations in the leucine rich repeat protein kinase 2 (LRRK2) gene are the most common cause of inherited Parkinson's disease (PD). LRRK2 is phosphorylated on a cluster of phosphosites including Ser(910), Ser(935), Ser(955) and Ser(973), which are dephosphorylated in several PD-relat...

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Detalles Bibliográficos
Autores principales:	Zhao, Jing, Molitor, Tyler P., Langston, J. William, Nichols, R. Jeremy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613513/ https://www.ncbi.nlm.nih.gov/pubmed/25939886 http://dx.doi.org/10.1042/BJ20141305

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