DNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B

APOBEC (apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like) is a family of enzymes that deaminates cytosine (C) to uracil (U) on nucleic acid. APOBEC3B (A3B) functions in innate immunity against intrinsic and invading retroelements and viruses. A3B can also induce genomic DNA mutations...

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Detalles Bibliográficos
Autores principales: Fu, Yang, Ito, Fumiaki, Zhang, Gewen, Fernandez, Braulio, Yang, Hanjing, Chen, Xiaojiang S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613526/
https://www.ncbi.nlm.nih.gov/pubmed/26195824
http://dx.doi.org/10.1042/BJ20150382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613526/
https://www.ncbi.nlm.nih.gov/pubmed/26195824
http://dx.doi.org/10.1042/BJ20150382

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