Structure-based design and functional studies of novel noroviral 3C protease chimaeras offer insights into substrate specificity

The norovirus NS6 protease is a key target for anti-viral drug development. Noroviruses encode a 2200 amino acid polyprotein which is cleaved by this critical protease at five defined boundary substrates into six mature non-structural (NS) proteins. Studies of the human norovirus (HNV) NS6 protease,...

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Detalles Bibliográficos
Autores principales: Herod, Morgan R., Prince, Cynthia A., Skilton, Rachel J., Ward, Vernon K., Cooper, Jonathan B., Clarke, Ian N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613530/
https://www.ncbi.nlm.nih.gov/pubmed/25275273
http://dx.doi.org/10.1042/BJ20140959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613530/
https://www.ncbi.nlm.nih.gov/pubmed/25275273
http://dx.doi.org/10.1042/BJ20140959

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