Cargando…
Structure-based design and functional studies of novel noroviral 3C protease chimaeras offer insights into substrate specificity
The norovirus NS6 protease is a key target for anti-viral drug development. Noroviruses encode a 2200 amino acid polyprotein which is cleaved by this critical protease at five defined boundary substrates into six mature non-structural (NS) proteins. Studies of the human norovirus (HNV) NS6 protease,...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Portland Press Ltd.
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613530/ https://www.ncbi.nlm.nih.gov/pubmed/25275273 http://dx.doi.org/10.1042/BJ20140959 |