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Molecular action of sulphonylureas on K(ATP) channels: a real partnership between drugs and nucleotides

Sulphonylureas stimulate insulin secretion from pancreatic β-cells primarily by closing ATP-sensitive K(+) channels in the β-cell plasma membrane. The mechanism of channel inhibition by these drugs is unusually complex. As direct inhibitors of channel activity, sulphonylureas act only as partial ant...

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Detalles Bibliográficos
Autores principales: de Wet, Heidi, Proks, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613533/
https://www.ncbi.nlm.nih.gov/pubmed/26517901
http://dx.doi.org/10.1042/BST20150096