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Molecular action of sulphonylureas on K(ATP) channels: a real partnership between drugs and nucleotides
Sulphonylureas stimulate insulin secretion from pancreatic β-cells primarily by closing ATP-sensitive K(+) channels in the β-cell plasma membrane. The mechanism of channel inhibition by these drugs is unusually complex. As direct inhibitors of channel activity, sulphonylureas act only as partial ant...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Portland Press Ltd.
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613533/ https://www.ncbi.nlm.nih.gov/pubmed/26517901 http://dx.doi.org/10.1042/BST20150096 |