Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

PLK (Polo-like kinase) inhibitors, such as BI-2536, have been reported to suppress IFNB (encoding IFNβ, interferon β) gene transcription induced by ligands that activate TLR3 (Toll-like receptor 3) and TLR4. In the present study, we found that BI-2536 is likely to exert this effect by preventing the...

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Detalles Bibliográficos
Autores principales: Malik, Nazma, Vollmer, Stefan, Nanda, Sambit Kumar, Lopez-Pelaez, Marta, Prescott, Alan, Gray, Nathanael, Cohen, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613535/
https://www.ncbi.nlm.nih.gov/pubmed/25891802
http://dx.doi.org/10.1042/BJ20141523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613535/
https://www.ncbi.nlm.nih.gov/pubmed/25891802
http://dx.doi.org/10.1042/BJ20141523

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