Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14

Rapidly proliferating cancer cells increase flux through anabolic pathways to build the mass necessary to support cell division. Imported amino acids and glucose lie at the apex of the anabolic pyramid. Consistent with this, elevated expression of nutrient transporter proteins is characteristic of a...

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Detalles Bibliográficos
Autores principales: McCracken, Alison N., Edinger, Aimee L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2015
Materias:
Commentary Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613721/
https://www.ncbi.nlm.nih.gov/pubmed/26341486
http://dx.doi.org/10.1042/BJ20150721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613721/
https://www.ncbi.nlm.nih.gov/pubmed/26341486
http://dx.doi.org/10.1042/BJ20150721

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