Cargando…

Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14

Rapidly proliferating cancer cells increase flux through anabolic pathways to build the mass necessary to support cell division. Imported amino acids and glucose lie at the apex of the anabolic pyramid. Consistent with this, elevated expression of nutrient transporter proteins is characteristic of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	McCracken, Alison N., Edinger, Aimee L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2015
Materias:	Commentary Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613721/ https://www.ncbi.nlm.nih.gov/pubmed/26341486 http://dx.doi.org/10.1042/BJ20150721

Ejemplares similares

Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14
por: Dejure, Francesca R., et al.
Publicado: (2020)

Unconventional Functions of Amino Acid Transporters: Role in Macropinocytosis (SLC38A5/SLC38A3) and Diet-Induced Obesity/Metabolic Syndrome (SLC6A19/SLC6A14/SLC6A6)
por: Bhutia, Yangzom D., et al.
Publicado: (2022)

Trach tubes designed to maximize safety may increase risk to ventilated patients
por: McCracken, John, et al.
Publicado: (2010)

SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion
por: Ahmadi, Saumel, et al.
Publicado: (2018)

Blockade of the amino acid transporter SLC6A14 suppresses tumor growth in colorectal Cancer
por: Lu, Ying, et al.
Publicado: (2022)

Trafficking of the amino acid transporter B(0,+) (SLC6A14) to the plasma membrane involves an exclusive interaction with SEC24C for its exit from the endoplasmic reticulum
por: Kovalchuk, Vasylyna, et al.
Publicado: (2018)

Towards a framework for implementing physician education in substance use disorders
por: Klimas, Jan, et al.
Publicado: (2021)

Amino Acid Transporter SLC6A14 (ATB(0,+)) – A Target in Combined Anti-cancer Therapy
por: Nałęcz, Katarzyna A.
Publicado: (2020)

Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATB(0,+)) Selectively Reduces Access for Cationic Amino Acids and Derivatives
por: Anderson, Catriona M. H., et al.
Publicado: (2022)

Pre-steady-state Kinetic Analysis of Amino Acid Transporter SLC6A14 Reveals Rapid Turnover Rate and Substrate Translocation
por: Shi, Yueyue, et al.
Publicado: (2021)

Commentary: Customized extended peeling of the internal limiting membrane
por: Ratra, Dhanashree
Publicado: (2022)

Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia
por: Deng, Xiangdong, et al.
Publicado: (2008)

Phosphorylated MLKL causes plasma membrane rupture
por: Linkermann, Andreas, et al.
Publicado: (2014)

Rushing to maintain plasma membrane phosphoinositide levels
por: Balla, Tamas
Publicado: (2020)

Commentary: Internal limiting membrane sparing in necrotizing focal retinitis
por: Dogra, Mohit, et al.
Publicado: (2020)

Commentary: Retinal changes after internal limiting membrane peeling
por: Babu, Naresh, et al.
Publicado: (2023)

When Do Microbes Stimulate Rheumatoid Factor?
por: Posnett, David N., et al.
Publicado: (1997)

External limiting membrane: retinal structural barrier in diabetic macular edema
por: Saxena, Sandeep, et al.
Publicado: (2021)

Untargeted metabolomics identifies the potential role of monocarboxylate transporter 6 (MCT6/SLC16A5) in lipid and amino acid metabolism pathways
por: Ren, Tianjing, et al.
Publicado: (2022)

SLC6A14, a Na(+)/Cl(−)-coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling
por: Sikder, Mohd O. F., et al.
Publicado: (2020)

Trafficking to the Cell Surface of Amino Acid Transporter SLC6A14 Upregulated in Cancer Is Controlled by Phosphorylation of SEC24C Protein by AKT Kinase
por: Kovalchuk, Vasylyna, et al.
Publicado: (2021)

SLC kicker magnet limitations
por: Cassel, R L, et al.
Publicado: (1991)

Plasma membrane repairs by small GTPase Rab3a
por: Raiborg, Camilla, et al.
Publicado: (2016)

Enhancing HIV Treatment Access and Outcomes Amongst HIV Infected Children and Adolescents in Resource Limited Settings
por: Goga, Ameena Ebrahim, et al.
Publicado: (2016)

Human solute carrier SLC6A14 is the β-alanine carrier
por: Anderson, Catriona M H, et al.
Publicado: (2008)

Transcriptomic and Immunohistochemical Profiling of SLC6A14 in Pancreatic Ductal Adenocarcinoma
por: Penheiter, Alan R., et al.
Publicado: (2015)

Metabolism of ciclesonide in the upper and lower airways: review of available data
por: Nave, Ruediger, et al.
Publicado: (2008)

Involvement of the Neutral Amino Acid Transporter SLC6A15 and Leucine in Obesity-Related Phenotypes
por: Drgonova, Jana, et al.
Publicado: (2013)

Limitations and Value of Animal Models of Relevance to the Schizophrenia Prodrome
por: Yung, Alison R.
Publicado: (2023)

SLC6A14 and SLC38A5 Drive the Glutaminolysis and Serine–Glycine–One-Carbon Pathways in Cancer
por: Sniegowski, Tyler, et al.
Publicado: (2021)

Dietary Supplements and Sports Performance: Amino Acids
por: Williams, Melvin
Publicado: (2005)

A bridge from the endoplasmic reticulum to the plasma membrane comes into view
por: Mahling, Ryan, et al.
Publicado: (2022)

Plasma Membrane Phosphatidylinositol 4-Phosphate Is Necessary for Virulence of Candida albicans
por: Konopka, James B.
Publicado: (2022)

Mechanisms for regulation of RAS palmitoylation and plasma membrane trafficking in hematopoietic malignancies
por: Yu, Fang, et al.
Publicado: (2023)

Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics
por: Finicle, Brendan T, et al.
Publicado: (2023)

Commentary: Considerations regarding area of internal limiting membrane peeling during macular hole surgery
por: Kumar, Atul, et al.
Publicado: (2020)

Lack of proportionality. Seven specifications of public interest that override post-approval commercial interests on limited access to clinical data
por: Strech, Daniel, et al.
Publicado: (2012)

Biochemical and histological study of granulation tissue to evaluate the effect of limited access dressing in chronic wounds: A comparative study
por: Behl, Air Mshl Anil, et al.
Publicado: (2015)

Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo
por: Lee, Donghoon M, et al.
Publicado: (2014)

RASSF4: Regulator of plasma membrane PI(4,5)P(2)
por: Dickson, Eamonn J.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_vcttufagpkp27ef7mvttnv9tj2