KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo

Kaposi's sarcoma herpesvirus (KSHV)-encoded v-cyclin, a homolog of cellular cyclin D2, activates cellular CDK6, promotes G1-S transition of the cell cycle, induces DNA damage, apoptosis, autophagy and is reported to have oncogenic potential. Here we show that in vivo expression of v-cyclin in t...

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Detalles Bibliográficos
Autores principales: Pekkonen, Pirita, Järviluoma, Annika, Zinovkina, Nadezhda, Cvrljevic, Anna, Prakash, Sonam, Westermarck, Jukka, Evan, Gerard I, Cesarman, Ethel, Verschuren, Emmy W, Ojala, Päivi M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613844/
https://www.ncbi.nlm.nih.gov/pubmed/25483078
http://dx.doi.org/10.4161/15384101.2014.964118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613844/
https://www.ncbi.nlm.nih.gov/pubmed/25483078
http://dx.doi.org/10.4161/15384101.2014.964118

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