An Umpolung Approach for the Chemoselective Arylation of Selenocysteine in Unprotected Peptides

[Image: see text] Herein we report an umpolung strategy for the bioconjugation of selenocysteine in unprotected peptides. This mild and operationally simple approach takes advantage of the electrophilic character of an oxidized selenocysteine (Se–S bond) to react with a nucleophilic arylboronic acid...

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Detalles Bibliográficos
Autores principales: Cohen, Daniel T., Zhang, Chi, Pentelute, Bradley L., Buchwald, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613869/
https://www.ncbi.nlm.nih.gov/pubmed/26225900
http://dx.doi.org/10.1021/jacs.5b05447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613869/
https://www.ncbi.nlm.nih.gov/pubmed/26225900
http://dx.doi.org/10.1021/jacs.5b05447

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