Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion

Type 2 diabetes incidence increases with age, while β-cell replication declines. The transcription factor FoxM1 is required for β-cell replication in various situations, and its expression declines with age. We hypothesized that increased FoxM1 activity in aged β-cells would rejuvenate proliferation...

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Detalles Bibliográficos
Autores principales: Golson, Maria L., Dunn, Jennifer C., Maulis, Matthew F., Dadi, Prasanna K., Osipovich, Anna B., Magnuson, Mark A., Jacobson, David A., Gannon, Maureen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613976/
https://www.ncbi.nlm.nih.gov/pubmed/26251404
http://dx.doi.org/10.2337/db15-0465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613976/
https://www.ncbi.nlm.nih.gov/pubmed/26251404
http://dx.doi.org/10.2337/db15-0465

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