Type 2 Diabetes–Associated K(+) Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis

Two-pore domain K(+) (K2P) channels play an important role in tuning β-cell glucose-stimulated insulin secretion (GSIS). The K2P channel TWIK-related alkaline pH-activated K2P (TALK)-1 is linked to type 2 diabetes risk through a coding sequence polymorphism (rs1535500); however, its physiological fu...

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Detalles Bibliográficos
Autores principales: Vierra, Nicholas C., Dadi, Prasanna K., Jeong, Imju, Dickerson, Matthew, Powell, David R., Jacobson, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613978/
https://www.ncbi.nlm.nih.gov/pubmed/26239056
http://dx.doi.org/10.2337/db15-0280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613978/
https://www.ncbi.nlm.nih.gov/pubmed/26239056
http://dx.doi.org/10.2337/db15-0280

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