A Novel, Potent, Small Molecule AKT Inhibitor Exhibits Efficacy against Lung Cancer Cells In Vitro

PURPOSE: Anomalies of Akt regulation, including overexpression in lung cancer, impart resistance to conventional chemotherapy and radiation, thereby implicating this kinase as a therapeutic intervention point. A novel scaffold of Akt inhibitors was developed through virtual screening of chemical dat...

Descripción completa

Detalles Bibliográficos
Autores principales: Dinavahi, Saketh S., Prasanna, Rajagopalan, Dharmarajan, Sriram, Perumal, Yogeeswari, Viswanadha, Srikant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614210/
https://www.ncbi.nlm.nih.gov/pubmed/25687876
http://dx.doi.org/10.4143/crt.2014.057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614210/
https://www.ncbi.nlm.nih.gov/pubmed/25687876
http://dx.doi.org/10.4143/crt.2014.057

Ejemplares similares