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A Novel, Potent, Small Molecule AKT Inhibitor Exhibits Efficacy against Lung Cancer Cells In Vitro

PURPOSE: Anomalies of Akt regulation, including overexpression in lung cancer, impart resistance to conventional chemotherapy and radiation, thereby implicating this kinase as a therapeutic intervention point. A novel scaffold of Akt inhibitors was developed through virtual screening of chemical dat...

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Detalles Bibliográficos
Autores principales:	Dinavahi, Saketh S., Prasanna, Rajagopalan, Dharmarajan, Sriram, Perumal, Yogeeswari, Viswanadha, Srikant
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Cancer Association 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614210/ https://www.ncbi.nlm.nih.gov/pubmed/25687876 http://dx.doi.org/10.4143/crt.2014.057

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