Cargando…

A Novel, Potent, Small Molecule AKT Inhibitor Exhibits Efficacy against Lung Cancer Cells In Vitro

PURPOSE: Anomalies of Akt regulation, including overexpression in lung cancer, impart resistance to conventional chemotherapy and radiation, thereby implicating this kinase as a therapeutic intervention point. A novel scaffold of Akt inhibitors was developed through virtual screening of chemical dat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dinavahi, Saketh S., Prasanna, Rajagopalan, Dharmarajan, Sriram, Perumal, Yogeeswari, Viswanadha, Srikant
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Cancer Association 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614210/ https://www.ncbi.nlm.nih.gov/pubmed/25687876 http://dx.doi.org/10.4143/crt.2014.057

Ejemplares similares

Discovery of Fused Triazolo-thiadiazoles as Inhibitors of TNF-alpha: Pharmacophore Hybridization for Treatment of Neuropathic Pain
por: Sharma, Monika, et al.
Publicado: (2012)

A small molecule inhibitor of dengue virus type 2 protease inhibits the replication of all four dengue virus serotypes in cell culture
por: Raut, Rajendra, et al.
Publicado: (2015)

Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes
por: Krátký, Martin, et al.
Publicado: (2014)

Novel Thiazolidinone-Azole Hybrids: Design, Synthesis and Antimycobacterial Activity Studies
por: Eroglu, Barbaros, et al.
Publicado: (2016)

N-methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo
por: Sebastian, Liba, et al.
Publicado: (2008)

Enhanced ranking of PknB Inhibitors using data fusion methods
por: Seal, Abhik, et al.
Publicado: (2013)

Depletion of M. tuberculosis GlmU from Infected Murine Lungs Effects the Clearance of the Pathogen
por: Soni, Vijay, et al.
Publicado: (2015)

Salubrinal in Combination With 4E1RCat Synergistically Impairs Melanoma Development by Disrupting the Protein Synthetic Machinery
por: Kardos, Gregory R., et al.
Publicado: (2020)

Mechanisims of asthma and allergic disease – 1094. Pre-clinical characterization of RP3133, a novel and potent CRAC channel inhibitor for the treatment of respiratory disorders
por: Routhu, Kasi Viswanath, et al.
Publicado: (2013)

Anti-cancer small molecule JP-8g exhibits potent in vivo anti-inflammatory activity
por: Sun, Yulong, et al.
Publicado: (2014)

Discovery of Highly Potent Small Molecule Pan-Coronavirus Fusion Inhibitors
por: Curreli, Francesca, et al.
Publicado: (2023)

Small-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity
por: Van Bael, Jens, et al.
Publicado: (2023)

Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents
por: Nalla, Viswanadh, et al.
Publicado: (2018)

Sparsomycin Exhibits Potent Antiplasmodial Activity In Vitro and In Vivo
por: Ariefta, Nanang Rudianto, et al.
Publicado: (2022)

Identification of potent and selective small molecule inhibitors of the cation channel TRPM4
por: Ozhathil, Lijo Cherian, et al.
Publicado: (2018)

CA-170 – A Potent Small-Molecule PD-L1 Inhibitor or Not?
por: Musielak, Bogdan, et al.
Publicado: (2019)

Design and Synthesis of Small Molecules as Potent Staphylococcus aureus Sortase A Inhibitors
por: Ha, Min Woo, et al.
Publicado: (2020)

Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors
por: Brotherton-Pleiss, Christine, et al.
Publicado: (2020)

Identification of potent small molecule inhibitors of SARS-CoV-2 entry
por: Mediouni, Sonia, et al.
Publicado: (2022)

Medicinal chemistry
por: Sriram, D, et al.
Publicado: (2010)

Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives
por: Kumar, Sriramoju Bharath, et al.
Publicado: (2013)

Potent Host-Directed Small-Molecule Inhibitors of Myxovirus RNA-Dependent RNA-Polymerases
por: Krumm, Stefanie A., et al.
Publicado: (2011)

Discovery of indole tetrafluorophenoxymethylketone-based potent novel small molecule inhibitors of caspase-3
por: Samiulla, Dodheri Syed, et al.
Publicado: (2012)

Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses
por: Bolken, Tove′ C., et al.
Publicado: (2006)

A potent and selective small molecule inhibitor of myoferlin attenuates colorectal cancer progression
por: He, Yuan, et al.
Publicado: (2021)

Targeting multiple response regulators of Mycobacterium tuberculosis augments the host immune response to infection
por: Banerjee, Srijon Kaushik, et al.
Publicado: (2016)

CT-721, a Potent Bcr-Abl Inhibitor, Exhibits Excellent In Vitro and In Vivo Efficacy in the Treatment of Chronic Myeloid Leukemia
por: Sun, Yinghui, et al.
Publicado: (2017)

Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1
por: Huang, Lynn YL, et al.
Publicado: (2014)

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma
por: Nakayama, Kazuhide, et al.
Publicado: (2018)

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors
por: Pietrobono, Silvia, et al.
Publicado: (2018)

Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor
por: Koblish, Holly K., et al.
Publicado: (2022)

Deep Learning Classifies Low- and High-Grade Glioma Patients with High Accuracy, Sensitivity, and Specificity Based on Their Brain White Matter Networks Derived from Diffusion Tensor Imaging
por: Vidyadharan, Sreejith, et al.
Publicado: (2022)

TPGS-1000 exhibits potent anticancer activity for hepatocellular carcinoma in vitro and in vivo
por: Chen, Yidan, et al.
Publicado: (2020)

VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis
por: Weber, Peter, et al.
Publicado: (2009)

Identification of Verrucarin A as a Potent and Selective Steroid Receptor Coactivator-3 Small Molecule Inhibitor
por: Yan, Fei, et al.
Publicado: (2014)

Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier
por: Shrestha, Neeta, et al.
Publicado: (2021)

Two small-molecule inhibitors of Toxoplasma gondii proliferation in vitro
por: Hua, Qian-qian, et al.
Publicado: (2023)

Hepatic Metabolic, Inflammatory, and Stress-Related Gene Expression in Growing Mice Consuming a Low Dose of Trans-10, cis-12-Conjugated Linoleic Acid
por: Li, Jing, et al.
Publicado: (2012)

HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells
por: Muralidharan, Ranganayaki, et al.
Publicado: (2017)

Small Molecule Inhibitors of the Response Regulator ArsR Exhibit Bactericidal Activity against Helicobacter pylori
por: González, Andrés, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bham5pn1g5pt50doaf0gf47a6g