Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation

Increasing evidence suggests that recurrent Herpes Simplex Virus type 1 (HSV-1) infection spreading to the CNS is a risk factor for Alzheimer’s Disease (AD) but the underlying mechanisms have not been fully elucidated yet. Here we demonstrate that in cultured mouse cortical neurons HSV-1 induced Ca(...

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Detalles Bibliográficos
Autores principales: Piacentini, Roberto, Li Puma, Domenica Donatella, Ripoli, Cristian, Elena Marcocci, Maria, De Chiara, Giovanna, Garaci, Enrico, Teresa Palamara, Anna, Grassi, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614347/
https://www.ncbi.nlm.nih.gov/pubmed/26487282
http://dx.doi.org/10.1038/srep15444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614347/
https://www.ncbi.nlm.nih.gov/pubmed/26487282
http://dx.doi.org/10.1038/srep15444

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