Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy

The Human Papillomavirus (HPV) E2 protein, which inhibits the E6 and E7 viral oncogenes, is believed to have anti-oncogenic properties. Here, we challenge this view and show that HPV-18 E2 over-activates the Spindle Assembly Checkpoint (SAC) and induces DNA breaks in mitosis followed by aneuploidy....

Descripción completa

Detalles Bibliográficos
Autores principales: Tan, Chye Ling, Teissier, Sébastien, Gunaratne, Jayantha, Quek, Ling Shih, Bellanger, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614697/
https://www.ncbi.nlm.nih.gov/pubmed/25789401
http://dx.doi.org/10.1080/15384101.2015.1021519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614697/
https://www.ncbi.nlm.nih.gov/pubmed/25789401
http://dx.doi.org/10.1080/15384101.2015.1021519

Ejemplares similares