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Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy
The Human Papillomavirus (HPV) E2 protein, which inhibits the E6 and E7 viral oncogenes, is believed to have anti-oncogenic properties. Here, we challenge this view and show that HPV-18 E2 over-activates the Spindle Assembly Checkpoint (SAC) and induces DNA breaks in mitosis followed by aneuploidy....
Autores principales: | Tan, Chye Ling, Teissier, Sébastien, Gunaratne, Jayantha, Quek, Ling Shih, Bellanger, Sophie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614697/ https://www.ncbi.nlm.nih.gov/pubmed/25789401 http://dx.doi.org/10.1080/15384101.2015.1021519 |
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