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Complex folding and misfolding effects of deer-specific amino acid substitutions in the β2-α2 loop of murine prion protein
The β2–α2 loop of PrP(C) is a key modulator of disease-associated prion protein misfolding. Amino acids that differentiate mouse (Ser169, Asn173) and deer (Asn169, Thr173) PrP(C) appear to confer dramatically different structural properties in this region and it has been suggested that amino acid se...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614821/ https://www.ncbi.nlm.nih.gov/pubmed/26490404 http://dx.doi.org/10.1038/srep15528 |