Complex folding and misfolding effects of deer-specific amino acid substitutions in the β2-α2 loop of murine prion protein

The β2–α2 loop of PrP(C) is a key modulator of disease-associated prion protein misfolding. Amino acids that differentiate mouse (Ser169, Asn173) and deer (Asn169, Thr173) PrP(C) appear to confer dramatically different structural properties in this region and it has been suggested that amino acid se...

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Detalles Bibliográficos
Autores principales: Agarwal, Sonya, Döring, Kristina, Gierusz, Leszek A., Iyer, Pooja, Lane, Fiona M., Graham, James F., Goldmann, Wilfred, Pinheiro, Teresa J. T., Gill, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614821/
https://www.ncbi.nlm.nih.gov/pubmed/26490404
http://dx.doi.org/10.1038/srep15528

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