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Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis
To maintain genome stability, the thousands of replication origins of mammalian genomes must only initiate replication once per cell cycle. This is achieved by a strict temporal separation of ongoing replication in S phase, and the formation of pre-replicative complexes in the preceding G1 phase, wh...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614858/ https://www.ncbi.nlm.nih.gov/pubmed/25875233 http://dx.doi.org/10.1080/15384101.2014.1000182 |