Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy

Spinal and bulbar muscular atrophy (SBMA) is characterized by loss of motoneurons and sensory neurons, accompanied by atrophy of muscle cells. SBMA is due to an androgen receptor containing a polyglutamine tract (ARpolyQ) that misfolds and aggregates, thereby perturbing the protein quality control (...

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Detalles Bibliográficos
Autores principales: Rusmini, Paola, Polanco, Maria Josefa, Cristofani, Riccardo, Cicardi, Maria Elena, Meroni, Marco, Galbiati, Mariarita, Piccolella, Margherita, Messi, Elio, Giorgetti, Elisa, Lieberman, Andrew P., Milioto, Carmelo, Rocchi, Anna, Aggarwal, Tanya, Pennuto, Maria, Crippa, Valeria, Poletti, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614888/
https://www.ncbi.nlm.nih.gov/pubmed/26490709
http://dx.doi.org/10.1038/srep15174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614888/
https://www.ncbi.nlm.nih.gov/pubmed/26490709
http://dx.doi.org/10.1038/srep15174

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