Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168

The mammalian E3 ubiquitin ligases RNF8 and RNF168 facilitate recruitment of the DNA damage response protein 53BP1 to sites of DNA double-strand breaks (DSBs). The mechanism involves recruitment of RNF8, followed by recruitment of RNF168, which ubiquitinates histones H2A/H2AX on K15. 53BP1 then bind...

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Detalles Bibliográficos
Autores principales: Kocyłowski, Maciej K, Rey, Alix J, Stewart, Grant S, Halazonetis, Thanos D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615105/
https://www.ncbi.nlm.nih.gov/pubmed/25695757
http://dx.doi.org/10.1080/15384101.2015.1010918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615105/
https://www.ncbi.nlm.nih.gov/pubmed/25695757
http://dx.doi.org/10.1080/15384101.2015.1010918

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