ABC-Transporter Expression Does Not Correlate with Response to Irinotecan in Patients with Metastatic Colorectal Cancer

Background: Active efflux of irinotecan by ATP-binding cassette (ABC)-transporters, in particular ABCB1 and ABCG2, is a well-established drug resistance mechanism in vitro and in pre-clinical mouse models, but its relevance in colorectal cancer (CRC) patients is unknown. Therefore, we assessed the a...

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Detalles Bibliográficos
Autores principales: Trumpi, K., Emmink, B.L., Prins, A.M., van Oijen, M.G.H., van Diest, P.J., Punt, C.J.A., Koopman, M., Kranenburg, O., Rinkes, I.H.M. Borel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615342/
https://www.ncbi.nlm.nih.gov/pubmed/26516354
http://dx.doi.org/10.7150/jca.12606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615342/
https://www.ncbi.nlm.nih.gov/pubmed/26516354
http://dx.doi.org/10.7150/jca.12606

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