Silencing of Survivin Expression Leads to Reduced Proliferation and Cell Cycle Arrest in Cancer Cells

Survivin is an anti-apoptotic gene that is overexpressed in most human tumors. RNA interference using short interfering RNA (siRNA) can be used to specifically inhibit survivin expression. Tumor cells were treated with a newly designed survivin siRNA, which was modified with 2′-OMe. Cellular survivi...

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Detalles Bibliográficos
Autores principales: Li, Yuhuan, Liu, Da, Zhou, Yulin, Li, Yujing, Xie, Jing, Lee, Robert J., Cai, Yong, Teng, Lesheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615356/
https://www.ncbi.nlm.nih.gov/pubmed/26516368
http://dx.doi.org/10.7150/jca.12437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615356/
https://www.ncbi.nlm.nih.gov/pubmed/26516368
http://dx.doi.org/10.7150/jca.12437

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