Loss of Glycosaminoglycan Receptor Binding after Mosquito Cell Passage Reduces Chikungunya Virus Infectivity

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause fever and chronic arthritis in humans. CHIKV that is generated in mosquito or mammalian cells differs in glycosylation patterns of viral proteins, which may affect its replication and virulence. Herein, we compare replicat...

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Detalles Bibliográficos
Autores principales: Acharya, Dhiraj, Paul, Amber M., Anderson, John F., Huang, Faqing, Bai, Fengwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615622/
https://www.ncbi.nlm.nih.gov/pubmed/26484530
http://dx.doi.org/10.1371/journal.pntd.0004139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615622/
https://www.ncbi.nlm.nih.gov/pubmed/26484530
http://dx.doi.org/10.1371/journal.pntd.0004139

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