Phosphatidic Acid (PA) can Displace PPARα/LXRα Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells

The expression of the epidermal growth factor receptor (EGFR) is highly regulated in normal cells, whereas some cancer cells have high constitutive levels. Understanding naturally-occurring ways of downregulating EGFR in cancer cells was investigated. Phosphatidic acid (PA) or Nuclear Receptors (NR)...

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Detalles Bibliográficos
Autores principales: Mahankali, Madhu, Farkaly, Terry, Bedi, Shimpi, Hostetler, Heather A., Gomez-Cambronero, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615983/
https://www.ncbi.nlm.nih.gov/pubmed/26493292
http://dx.doi.org/10.1038/srep15379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615983/
https://www.ncbi.nlm.nih.gov/pubmed/26493292
http://dx.doi.org/10.1038/srep15379

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