Gender-Dimorphic Impact of PXR Genotype and Haplotype on Hepatotoxicity During Antituberculosis Treatment

Women have a higher risk of drug-induced hepatotoxicity during antituberculosis treatment (HATT) than men. We hypothesized that single nucleotide polymorphism (SNP) genotype and derived haplotype of pregnane X receptor (PXR) gene, which could regulate the expression of phase I enzyme cytochrome P450...

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Detalles Bibliográficos
Autores principales: Wang, Jann Yuan, Tsai, Ching Hui, Lee, Yungling Leo, Lee, Li Na, Hsu, Chia Lin, Chang, Hsiu Ching, Chen, Jong Ming, Hsu, Cheng An, Yu, Chong Jen, Yang, Pan Chyr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
4900
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616541/
https://www.ncbi.nlm.nih.gov/pubmed/26091473
http://dx.doi.org/10.1097/MD.0000000000000982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616541/
https://www.ncbi.nlm.nih.gov/pubmed/26091473
http://dx.doi.org/10.1097/MD.0000000000000982

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