Cargando…

Adiposity significantly modifies genetic risk for dyslipidemia

Recent genome-wide association studies have identified multiple loci robustly associated with plasma lipids, which also contribute to extreme lipid phenotypes. However, these common genetic variants explain <12% of variation in lipid traits. Adiposity is also an important determinant of plasma li...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cole, Christopher B., Nikpay, Majid, Lau, Paulina, Stewart, Alexandre F. R., Davies, Robert W., Wells, George A., Dent, Robert, McPherson, Ruth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2014
Materias:	Patient-Oriented and Epidemiological Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617143/ https://www.ncbi.nlm.nih.gov/pubmed/25225679 http://dx.doi.org/10.1194/jlr.P052522

Ejemplares similares

Statin action favors normalization of the plasma lipidome in the atherogenic mixed dyslipidemia of MetS: potential relevance to statin-associated dysglycemia
por: Meikle, Peter J., et al.
Publicado: (2015)

Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial
por: Liu, Yanhong, et al.
Publicado: (2017)

Plasma proteome correlates of lipid and lipoprotein: biomarkers of metabolic diversity and inflammation in children of rural Nepal
por: Lee, Sun Eun, et al.
Publicado: (2019)

The relationship between non-HDL cholesterol and macrophage phenotypes in human adipose tissue
por: Poledne, Rudolf, et al.
Publicado: (2016)

Association between serum phospholipid fatty acid levels and adiposity in Mexican women
por: Aglago, Elom K., et al.
Publicado: (2017)

Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations
por: Pelosi, Michele, et al.
Publicado: (2017)

Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C
por: Hellstrand, S., et al.
Publicado: (2012)

Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes
por: Connelly, Philip W., et al.
Publicado: (2009)

LDL-C calculated by Friedewald, Martin-Hopkins, or NIH equation 2 versus beta-quantification: pooled alirocumab trials
por: Ginsberg, Henry N., et al.
Publicado: (2021)

Use of next-generation sequencing to detect LDLR gene copy number variation in familial hypercholesterolemia
por: Iacocca, Michael A., et al.
Publicado: (2017)

Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea
por: Gluchowski, Nina L., et al.
Publicado: (2017)

Acetyl-CoA carboxylase inhibitor increases LDL-apoB production rate in NASH with cirrhosis: prevention by fenofibrate
por: Dandan, Mohamad, et al.
Publicado: (2023)

Large-scale deletions of the ABCA1 gene in patients with hypoalphalipoproteinemia
por: Dron, Jacqueline S., et al.
Publicado: (2018)

Polygenic determinants in extremes of high-density lipoprotein cholesterol
por: Dron, Jacqueline S., et al.
Publicado: (2017)

Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a)
por: Deshmukh, Harshal A., et al.
Publicado: (2012)

Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity
por: Rubinow, Katya B., et al.
Publicado: (2012)

Plasma apolipoprotein O level increased in the patients with acute coronary syndrome
por: Yu, Bi-lian, et al.
Publicado: (2012)

Effects of Therapeutic Lifestyle Change diets high and low in dietary fish-derived FAs on lipoprotein metabolism in middle-aged and elderly subjects
por: Ooi, Esther M. M., et al.
Publicado: (2012)

Effects of prescription niacin and omega-3 fatty acids on lipids and vascular function in metabolic syndrome: a randomized controlled trial
por: Shearer, Gregory C., et al.
Publicado: (2012)

Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis
por: Gaspar, Paulo, et al.
Publicado: (2014)

New insights regarding tissue Se and Hg interactions on oxidative stress from plasma IsoP and IsoF measures in the Canadian Inuit population
por: Alkazemi, Dalal, et al.
Publicado: (2013)

Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies(1)
por: Tsiantoulas, Dimitrios, et al.
Publicado: (2015)

The implication of cigarette smoking and cessation on macrophage cholesterol efflux in coronary artery disease patients
por: Song, Wei, et al.
Publicado: (2015)

Genetic loci associated with circulating levels of very long-chain saturated fatty acids
por: Lemaitre, Rozenn N., et al.
Publicado: (2015)

Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene
por: Saito, Yoshiro, et al.
Publicado: (2015)

Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans
por: Bonde, Ylva, et al.
Publicado: (2014)

Identification of a novel mutation in the PNLIP gene in two brothers with congenital pancreatic lipase deficiency
por: Behar, Doron M., et al.
Publicado: (2014)

Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men
por: McManus, Seán, et al.
Publicado: (2016)

Defective cholesterol metabolism in amyotrophic lateral sclerosis
por: Abdel-Khalik, Jonas, et al.
Publicado: (2017)

Diabetes adversely affects phospholipid profiles in human carotid artery endarterectomy plaques
por: Zayed, Mohamed A., et al.
Publicado: (2018)

Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS
por: Mazaleuskaya, Liudmila L., et al.
Publicado: (2018)

Cerebral organoids derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation
por: Allende, Maria L., et al.
Publicado: (2018)

HDL functionality and cardiovascular outcome among nondialysis chronic kidney disease patients
por: Untersteller, Kathrin, et al.
Publicado: (2018)

Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results(1)
por: Kaysen, George A., et al.
Publicado: (2018)

Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis
por: Valdes, Ana M., et al.
Publicado: (2018)

Effects of oils and solid fats on blood lipids: a systematic review and network meta-analysis
por: Schwingshackl, Lukas, et al.
Publicado: (2018)

Abnormal liver phosphatidylcholine synthesis revealed in patients with acute respiratory distress syndrome
por: Dushianthan, Ahilanandan, et al.
Publicado: (2018)

Scavenger receptor BI promotes cytoplasmic accumulation of lipoproteins in clear-cell renal cell carcinoma
por: Velagapudi, Srividya, et al.
Publicado: (2018)

Does pregnancy alter life-course lipid trajectories? Evidence from the HUNT Study in Norway
por: Markovitz, Amanda R., et al.
Publicado: (2018)

Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia
por: Sokolov, Victor, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1m4hi0akn9ea5lllju6m44klvk