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Relative Binding Free Energies of Adenine and Guanine to Damaged and Undamaged DNA in Human DNA Polymerase η: Clues for Fidelity and Overall Efficiency
[Image: see text] Human DNA polymerase η (Pol η) plays an essential protective role against skin cancer caused by cyclobutane thymine–thymine dimers (TTDs), a frequent form of DNA damage arising from exposure to the sun. This enzyme rescues stalled replication forks at the TTDs by inserting bases op...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617179/ https://www.ncbi.nlm.nih.gov/pubmed/26434497 http://dx.doi.org/10.1021/jacs.5b08451 |