Cyclosporin A induced toxicity in mouse liver slices is only slightly aggravated by Fxr-deficiency and co-occurs with upregulation of pro-inflammatory genes and downregulation of genes involved in mitochondrial functions

BACKGROUND: The transcription factor farnesoid X receptor (FXR) governs bile acid and energy homeostasis, is involved in inflammation, and has protective functions in the liver. In the present study we investigated the effect of Fxr deficiency in mouse precision cut liver slices (PCLS) exposed to a...

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Detalles Bibliográficos
Autores principales: Szalowska, Ewa, Pronk, Tessa E., Peijnenburg, Ad ACM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617705/
https://www.ncbi.nlm.nih.gov/pubmed/26482353
http://dx.doi.org/10.1186/s12864-015-2054-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617705/
https://www.ncbi.nlm.nih.gov/pubmed/26482353
http://dx.doi.org/10.1186/s12864-015-2054-7

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