Spectroscopic and computational studies of nitrile hydratase: insights into geometric and electronic structure and the mechanism of amide synthesis

Nitrile hydratases (NHases) are mononuclear nonheme enzymes that catalyze the hydration of nitriles to amides. NHase is unusual in that it utilizes a low-spin (LS) Fe(III) center and a unique ligand set comprised of two deprotonated backbone amides, cysteine-based sulfenic acid (RSO(H)) and sulfinic...

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Detalles Bibliográficos
Autores principales: Light, Kenneth M., Yamanaka, Yasuaki, Odaka, Masafumi, Solomon, Edward I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618400/
https://www.ncbi.nlm.nih.gov/pubmed/26508996
http://dx.doi.org/10.1039/c5sc02012c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618400/
https://www.ncbi.nlm.nih.gov/pubmed/26508996
http://dx.doi.org/10.1039/c5sc02012c

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