Cargando…

New Insights into Orphan Nuclear Receptor SHP in Liver Cancer

Small heterodimer partner (SHP; NR0B2) is a unique orphan nuclear receptor (NR) that contains a putative ligand-binding domain but lacks a DNA-binding domain. SHP is a transcriptional corepressor affecting diverse metabolic processes including bile acid synthesis, cholesterol and lipid metabolism, g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zou, An, Lehn, Sarah, Magee, Nancy, Zhang, Yuxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618403/ https://www.ncbi.nlm.nih.gov/pubmed/26504773 http://dx.doi.org/10.11131/2015/101162

Ejemplares similares

The Orphan Nuclear Receptor SHP Is a Positive Regulator of Osteoblastic Bone Formation
por: Jeong, Byung-Chul, et al.
Publicado: (2010)

The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation
por: Sun, Shengyi, et al.
Publicado: (2019)

Loss of the Orphan Nuclear Receptor SHP Is More Pronounced in Fibrolamellar Carcinoma than in Typical Hepatocellular Carcinoma
por: Wilczek, Ewa, et al.
Publicado: (2012)

Retraction Note: Distinct Repressive Properties of the Mammalian and Fish Orphan Nuclear Receptors SHP and DAX-1
por: Park, Yun-Yong, et al.
Publicado: (2018)

Cross-Regulation of Protein Stability by p53 and Nuclear Receptor SHP
por: Yang, Zhihong, et al.
Publicado: (2012)

Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression
por: Kim, Don-Kyu, et al.
Publicado: (2016)

Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP
por: Zhang, Yuxia, et al.
Publicado: (2012)

Nuclear receptors FXR and SHP regulate protein N-glycan modifications in the liver
por: Mathur, Bhoomika, et al.
Publicado: (2021)

Characterization of the Mitochondrial Localization of the Nuclear Receptor SHP and Regulation of Its Subcellular Distribution by Interaction with Bcl2 and HNF4α
por: Zhang, Yuxia, et al.
Publicado: (2013)

Role of early growth response 1 in liver metabolism and liver cancer
por: Magee, Nancy, et al.
Publicado: (2017)

Insights into Orphan Nuclear Receptors as Prognostic Markers and Novel Therapeutic Targets for Breast Cancer
por: Aesoy, Reidun, et al.
Publicado: (2015)

Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis
por: Cipriani, Sabrina, et al.
Publicado: (2017)

Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer
por: Garattini, Enrico, et al.
Publicado: (2016)

Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells
por: Magee, Nancy, et al.
Publicado: (2016)

An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRγ
por: Park, Yun-Yong, et al.
Publicado: (2005)

An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRγ
por: Park, Yun-Yong, et al.
Publicado: (2018)

An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRγ
por: Park, Yun-Yong, et al.
Publicado: (2019)

ONRLDB—manually curated database of experimentally validated ligands for orphan nuclear receptors: insights into new drug discovery
por: Nanduri, Ravikanth, et al.
Publicado: (2015)

The Orphan Nuclear Receptor Gene NR0B2 Is a Favorite Prognosis Factor Modulated by Multiple Cellular Signal Pathways in Human Liver Cancers
por: Zhu, Runzhi, et al.
Publicado: (2021)

Dichotomous roles for the orphan nuclear receptor NURR1 in breast cancer
por: Llopis, Shawn, et al.
Publicado: (2013)

The role of the orphan nuclear receptor COUP-TFII in tumorigenesis
por: Xu, Mafei, et al.
Publicado: (2015)

Comprehensive insights into the function and molecular and pharmacological regulation of neuron-derived orphan receptor 1, an orphan receptor
por: Hong, Hongxiang, et al.
Publicado: (2022)

Nuclear Receptor Small Heterodimer Partner in Apoptosis Signaling and Liver Cancer
por: Zhang, Yuxia, et al.
Publicado: (2011)

Structural basis for corepressor assembly by the orphan nuclear receptor TLX
por: Zhi, Xiaoyong, et al.
Publicado: (2015)

New Drug Candidate Targeting the 4A1 Orphan Nuclear Receptor for Medullary Thyroid Cancer Therapy
por: Zhang, Lei, et al.
Publicado: (2018)

Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes
por: Zhang, Chenyang, et al.
Publicado: (2020)

Orphan receptors.
Publicado: (1993)

Testicular orphan nuclear receptor 4-associated protein 16 promotes non-small cell lung carcinoma by activating estrogen receptor β and blocking testicular orphan nuclear receptor 2
por: FANG, FANG, et al.
Publicado: (2012)

Orphan nuclear receptor TLX regulates astrogenesis by modulating BMP signaling
por: Qin, Song, et al.
Publicado: (2014)

The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases
por: Zhang, Lei, et al.
Publicado: (2018)

Isoforms of the orphan nuclear receptor COUP-TFII differentially modulate pancreatic cancer progression
por: Polvani, Simone, et al.
Publicado: (2022)

The Coup-TFII orphan nuclear receptor is an activator of the γ-globin gene
por: Fugazza, Cristina, et al.
Publicado: (2020)

Orphan nuclear receptors as regulators of intratumoral androgen biosynthesis in castration-resistant prostate cancer
por: Zhou, Jianfu, et al.
Publicado: (2021)

In Silico Adoption of an Orphan Nuclear Receptor NR4A1
por: Lanig, Harald, et al.
Publicado: (2015)

Identification of an Endogenous Ligand Bound to a Native Orphan Nuclear Receptor
por: Yuan, Xiaohui, et al.
Publicado: (2009)

The Orphan Nuclear Receptor Liver Homolog Receptor-1 (Nr5a2) Regulates Ovarian Granulosa Cell Proliferation
por: Meinsohn, Marie-Charlotte, et al.
Publicado: (2017)

SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor
por: Chen, Lin, et al.
Publicado: (2023)

Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated Receptor
por: Kruse, Schoen W, et al.
Publicado: (2008)

Orphan Nuclear Receptor Nur77 Regulates Androgen Receptor Gene Expression in Mouse Ovary
por: Dai, Anyi, et al.
Publicado: (2012)

Nuclear receptor retinoid-related orphan receptor alpha promotes apoptosis but is reduced in human gastric cancer
por: Wang, Zhengguang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_brkn7ccdiiifqrpd4bv6qg3h5f