O-GlcNAc modification blocks the aggregation and toxicity of the Parkinson’s disease associated protein α-synuclein

Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating-protein associated with synucleinopathies, including Parkinson’s disease. However, the effect...

Descripción completa

Detalles Bibliográficos
Autores principales: Marotta, Nicholas P., Lin, Yu Hsuan, Lewis, Yuka E., Ambroso, Mark R., Zaro, Balyn W., Roth, Maxwell T., Arnold, Don B., Langen, Ralf, Pratt, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618406/
https://www.ncbi.nlm.nih.gov/pubmed/26492012
http://dx.doi.org/10.1038/nchem.2361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618406/
https://www.ncbi.nlm.nih.gov/pubmed/26492012
http://dx.doi.org/10.1038/nchem.2361

Ejemplares similares