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O-GlcNAc modification blocks the aggregation and toxicity of the Parkinson’s disease associated protein α-synuclein
Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating-protein associated with synucleinopathies, including Parkinson’s disease. However, the effect...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618406/ https://www.ncbi.nlm.nih.gov/pubmed/26492012 http://dx.doi.org/10.1038/nchem.2361 |