Inhibition of non-homologous end joining increases the efficiency of CRISPR/Cas9-mediated precise [TM: inserted] genome editing

Methods to introduce targeted double-strand breaks (DSBs) into DNA enable precise genome editing by increasing the rate at which externally supplied DNA fragments are incorporated into the genome through homologous recombination. The efficiency of these methods is limited by non-homologous end joini...

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Detalles Bibliográficos
Autores principales: Maruyama, Takeshi, Dougan, Stephanie K., Truttmann, Matthias, Bilate, Angelina M., Ingram, Jessica R., Ploegh, Hidde L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618510/
https://www.ncbi.nlm.nih.gov/pubmed/25798939
http://dx.doi.org/10.1038/nbt.3190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618510/
https://www.ncbi.nlm.nih.gov/pubmed/25798939
http://dx.doi.org/10.1038/nbt.3190

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