Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine

Mexiletine is a sodium channel blocker, primarily used in the treatment of ventricular arrhythmias. Moreover, recent studies have demonstrated its therapeutic value to treat myotonic syndromes and to relieve neuropathic pain. The present study aims at investigating the direct blockade of hERG potass...

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Detalles Bibliográficos
Autores principales: Gualdani, Roberta, Tadini-Buoninsegni, Francesco, Roselli, Mariagrazia, Defrenza, Ivana, Contino, Marialessandra, Colabufo, Nicola Antonio, Lentini, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618635/
https://www.ncbi.nlm.nih.gov/pubmed/26516576
http://dx.doi.org/10.1002/prp2.160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618635/
https://www.ncbi.nlm.nih.gov/pubmed/26516576
http://dx.doi.org/10.1002/prp2.160

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