In silico identified targeted inhibitors of P-glycoprotein overcome multidrug resistance in human cancer cells in culture

Failure of cancer chemotherapies is often linked to the over expression of ABC efflux transporters like the multidrug resistance P-glycoprotein (P-gp). P-gp expression in cells leads to the elimination of a variety of chemically unrelated, mostly cytotoxic compounds. Administration of chemotherapeut...

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Detalles Bibliográficos
Autores principales: Follit, Courtney A, Brewer, Frances K, Wise, John G, Vogel, Pia D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618641/
https://www.ncbi.nlm.nih.gov/pubmed/26516582
http://dx.doi.org/10.1002/prp2.170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618641/
https://www.ncbi.nlm.nih.gov/pubmed/26516582
http://dx.doi.org/10.1002/prp2.170

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