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In silico identified targeted inhibitors of P-glycoprotein overcome multidrug resistance in human cancer cells in culture
Failure of cancer chemotherapies is often linked to the over expression of ABC efflux transporters like the multidrug resistance P-glycoprotein (P-gp). P-gp expression in cells leads to the elimination of a variety of chemically unrelated, mostly cytotoxic compounds. Administration of chemotherapeut...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Ltd
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618641/ https://www.ncbi.nlm.nih.gov/pubmed/26516582 http://dx.doi.org/10.1002/prp2.170 |