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Interrogating the relationship between rat in vivo tissue distribution and drug property data for >200 structurally unrelated molecules
The ability to explain distribution patterns from drug physicochemical properties and binding characteristics has been explored for more than 200 compounds by interrogating data from quantitative whole body autoradiography studies (QWBA). These in vivo outcomes have been compared to in silico and in...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Ltd
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618644/ https://www.ncbi.nlm.nih.gov/pubmed/26516585 http://dx.doi.org/10.1002/prp2.173 |